Path ID: DB09079_MESH_D002289_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C530716 | nintedanib | Drug |
| UniProt:P35236 | Tyrosine-protein phosphatase non-receptor type | Protein |
| UniProt:P17948 | Vascular endothelial growth factor receptor 1 | Protein |
| UniProt:P35968 | Vascular endothelial growth factor receptor 2 | Protein |
| UniProt:P35916 | Vascular endothelial growth factor receptor 3 | Protein |
| InterPro:IPR006782 | Platelet-derived growth factor, N-terminal | GeneFamily |
| InterPro:IPR016248 | Fibroblast growth factor receptor family | GeneFamily |
| reactome:R-HSA-162582 | Signal Transduction | Pathway |
| reactome:R-HSA-5218921 | VEGFR2 mediated cell proliferation | Pathway |
| reactome:R-HSA-186797 | Signaling by PDGF | Pathway |
| reactome:R-HSA-190236 | Signaling by FGFR | Pathway |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nintedanib | DECREASES ACTIVITY OF | Tyrosine-Protein Phosphatase Non-Receptor Type |
| Nintedanib | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor Receptor 1 |
| Nintedanib | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor Receptor 2 |
| Nintedanib | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor Receptor 3 |
| Nintedanib | DECREASES ACTIVITY OF | Platelet-Derived Growth Factor, N-Terminal |
| Nintedanib | DECREASES ACTIVITY OF | Fibroblast Growth Factor Receptor Family |
| Tyrosine-Protein Phosphatase Non-Receptor Type | PARTICIPATES IN | Signal Transduction |
| Vascular Endothelial Growth Factor Receptor 1 | PARTICIPATES IN | Vegfr2 Mediated Cell Proliferation |
| Vascular Endothelial Growth Factor Receptor 2 | PARTICIPATES IN | Vegfr2 Mediated Cell Proliferation |
| Vascular Endothelial Growth Factor Receptor 3 | PARTICIPATES IN | Vegfr2 Mediated Cell Proliferation |
| Platelet-Derived Growth Factor, N-Terminal | PARTICIPATES IN | Signaling By Pdgf |
| Fibroblast Growth Factor Receptor Family | PARTICIPATES IN | Signaling By Fgfr |
| Signal Transduction | POSITIVELY REGULATES | Cell Population Proliferation |
| Vegfr2 Mediated Cell Proliferation | POSITIVELY REGULATES | Cell Population Proliferation |
| Signaling By Pdgf | POSITIVELY REGULATES | Cell Population Proliferation |
| Signaling By Fgfr | POSITIVELY REGULATES | Cell Population Proliferation |
| Cell Population Proliferation | CONTRIBUTES TO | Carcinoma, Non-Small-Cell Lung |
Reference:
- https://go.drugbank.com/drugs/DB09079#mechanism-of-action
- https://en.wikipedia.org/wiki/Nintedanib#Mechanism_of_action
- https://www.uniprot.org/uniprot/P35236#function
- https://www.uniprot.org/uniprot/P17948#function
- https://www.uniprot.org/uniprot/P35968#function
- https://www.uniprot.org/uniprot/P35916#function
- https://www.ncbi.nlm.nih.gov/books/NBK585049/
- https://en.wikipedia.org/wiki/Non-small-cell_lung_cancer