Path ID: DB09079_MESH_D000080203_1

db09079-mesh-d000080203-1

Concepts

Identifier Name Type
MESH:C530716 nintedanib Drug
UniProt:P35236 Tyrosine-protein phosphatase non-receptor type Protein
UniProt:P17948 Vascular endothelial growth factor receptor 1 Protein
UniProt:P35968 Vascular endothelial growth factor receptor 2 Protein
UniProt:P35916 Vascular endothelial growth factor receptor 3 Protein
InterPro:IPR006782 Platelet-derived growth factor, N-terminal GeneFamily
InterPro:IPR016248 Fibroblast growth factor receptor family GeneFamily
reactome:R-HSA-162582 Signal Transduction Pathway
reactome:R-HSA-5218921 VEGFR2 mediated cell proliferation Pathway
reactome:R-HSA-186797 Signaling by PDGF Pathway
reactome:R-HSA-190236 Signaling by FGFR Pathway
GO:0048144 fibroblast proliferation BiologicalProcess
MESH:D000080203 Hamman-Rich Syndrome Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Nintedanib DECREASES ACTIVITY OF Tyrosine-Protein Phosphatase Non-Receptor Type
Nintedanib DECREASES ACTIVITY OF Vascular Endothelial Growth Factor Receptor 1
Nintedanib DECREASES ACTIVITY OF Vascular Endothelial Growth Factor Receptor 2
Nintedanib DECREASES ACTIVITY OF Vascular Endothelial Growth Factor Receptor 3
Nintedanib DECREASES ACTIVITY OF Platelet-Derived Growth Factor, N-Terminal
Nintedanib DECREASES ACTIVITY OF Fibroblast Growth Factor Receptor Family
Tyrosine-Protein Phosphatase Non-Receptor Type PARTICIPATES IN Signal Transduction
Vascular Endothelial Growth Factor Receptor 1 PARTICIPATES IN Vegfr2 Mediated Cell Proliferation
Vascular Endothelial Growth Factor Receptor 2 PARTICIPATES IN Vegfr2 Mediated Cell Proliferation
Vascular Endothelial Growth Factor Receptor 3 PARTICIPATES IN Vegfr2 Mediated Cell Proliferation
Platelet-Derived Growth Factor, N-Terminal PARTICIPATES IN Signaling By Pdgf
Fibroblast Growth Factor Receptor Family PARTICIPATES IN Signaling By Fgfr
Signal Transduction POSITIVELY REGULATES Fibroblast Proliferation
Vegfr2 Mediated Cell Proliferation POSITIVELY REGULATES Fibroblast Proliferation
Signaling By Pdgf POSITIVELY REGULATES Fibroblast Proliferation
Signaling By Fgfr POSITIVELY REGULATES Fibroblast Proliferation
Fibroblast Proliferation CONTRIBUTES TO Hamman-Rich Syndrome

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