Path ID: DB09076_MESH_D029424_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C573971 | umeclidinium | Drug |
| UniProt:P08172 | Muscarinic acetylcholine receptor M2 | Protein |
| UniProt:P20309 | Muscarinic acetylcholine receptor M3 | Protein |
| GO:1905144 | response to acetylcholine | BiologicalProcess |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| UBERON:0002185 | bronchus | GrossAnatomicalStructure |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D029424 | Chronic obstructive lung disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Umeclidinium | DECREASES ACTIVITY OF | Muscarinic Acetylcholine Receptor M2 |
| Umeclidinium | DECREASES ACTIVITY OF | Muscarinic Acetylcholine Receptor M3 |
| Muscarinic Acetylcholine Receptor M2 | PARTICIPATES IN | Response To Acetylcholine |
| Muscarinic Acetylcholine Receptor M3 | PARTICIPATES IN | Response To Acetylcholine |
| Response To Acetylcholine | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | LOCATED IN | Bronchus |
| Bronchus | LOCATION OF | Inflammatory Response |
| Inflammatory Response | CAUSES | Chronic Obstructive Lung Disease |
Reference: