Path ID: DB09074_MESH_D010051_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C531550 | Olaparib | Drug |
| UniProt:P09874 | Poly [ADP-ribose] polymerase 1 | Protein |
| UniProt:Q9UGN5 | Poly [ADP-ribose] polymerase 2 | Protein |
| UniProt:Q9Y6F1 | Poly [ADP-ribose] polymerase 3 | Protein |
| GO:0006281 | DNA repair | BiologicalProcess |
| GO:0008219 | Cell death | BiologicalProcess |
| GO:0007048 | Obsolete oncogenesis | BiologicalProcess |
| MESH:D010051 | Malignant tumor of ovary | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Olaparib | DECREASES ACTIVITY OF | Poly [Adp-Ribose] Polymerase 1 |
| Olaparib | DECREASES ACTIVITY OF | Poly [Adp-Ribose] Polymerase 2 |
| Olaparib | DECREASES ACTIVITY OF | Poly [Adp-Ribose] Polymerase 3 |
| Poly [Adp-Ribose] Polymerase 1 | POSITIVELY REGULATES | Dna Repair |
| Poly [Adp-Ribose] Polymerase 2 | POSITIVELY REGULATES | Dna Repair |
| Poly [Adp-Ribose] Polymerase 3 | POSITIVELY REGULATES | Dna Repair |
| Dna Repair | PREVENTS | Cell Death |
| Cell Death | NEGATIVELY CORRELATED WITH | Obsolete Oncogenesis |
| Obsolete Oncogenesis | POSITIVELY CORRELATED WITH | Malignant Tumor Of Ovary |
Comment: Commonly recommended for a treatment of ovarian cancer patients with deleterious or suspected deleterious germline BRCA-mutations
Reference: