Path ID: DB09072_MESH_D009290_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D012978 | Sodium oxybate | Drug |
| GO:0016917 | GABA receptor activity | MolecularActivity |
| UniProt:Q9UBS5 | Gamma-aminobutyric acid type B receptor subunit 1 | Protein |
| MESH:D009290 | Cataplexy and narcolepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sodium Oxybate | INCREASES ACTIVITY OF | Gamma-Aminobutyric Acid Type B Receptor Subunit 1 |
| Gamma-Aminobutyric Acid Type B Receptor Subunit 1 | PARTICIPATES IN | Gaba Receptor Activity |
| Gaba Receptor Activity | TREATS | Cataplexy And Narcolepsy |
Comment: The exact mechanism of action of sodium oxybate for treating narcolepsy and cataplexy is not known but is is hypothesised that its therapeutic effects are due to GABA(B) effects on noradrenergic, dopaminaergic and thalamocorticol neurons.
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