Path ID: DB09068_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C557874 | vortioxetine | Drug |
| UniProt:P31645 | Sodium-dependent serotonin transporter | Protein |
| GO:0051610 | Serotonin uptake | BiologicalProcess |
| MESH:D012701 | Serotonin | ChemicalSubstance |
| GO:0060096 | Serotonin secretion, neurotransmission | BiologicalProcess |
| UniProt:P08908 | 5-hydroxytryptamine receptor 1A | Protein |
| UniProt:P46098 | 5-hydroxytryptamine receptor 3A | Protein |
| UniProt:P34969 | 5-hydroxytryptamine receptor 7 | Protein |
| UniProt:P28222 | 5-hydroxytryptamine receptor 1B | Protein |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Vortioxetine | DECREASES ACTIVITY OF | Sodium-Dependent Serotonin Transporter |
| Sodium-Dependent Serotonin Transporter | POSITIVELY REGULATES | Serotonin Uptake |
| Serotonin Uptake | DECREASES ABUNDANCE OF | Serotonin |
| Serotonin | POSITIVELY CORRELATED WITH | Serotonin Secretion, Neurotransmission |
| Vortioxetine | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 1A |
| Vortioxetine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 3A |
| Vortioxetine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 7 |
| Vortioxetine | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 1B |
| 5-Hydroxytryptamine Receptor 3A | MOLECULARLY INTERACTS WITH | Serotonin |
| 5-Hydroxytryptamine Receptor 1A | MOLECULARLY INTERACTS WITH | Serotonin |
| 5-Hydroxytryptamine Receptor 7 | MOLECULARLY INTERACTS WITH | Serotonin |
| 5-Hydroxytryptamine Receptor 1B | MOLECULARLY INTERACTS WITH | Serotonin |
| Serotonin Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Major Depressive Disorder |
Comment: Vortioxetine is classified as a serotonin modulator. How it works is not entirely clear but is believed to be related to increasing serotonin levels.
Reference: