Path ID: DB09065_MESH_D015658_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069547 | cobicistat | Drug |
| InterPro:IPR001128 | Cytochrome P450 | GeneFamily |
| GO:0042178 | xenobiotic catabolic process | BiologicalProcess |
| CHEBI:22587 | antiviral agent | ChemicalSubstance |
| MESH:D015658 | Human immunodeficiency virus infection | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cobicistat | NEGATIVELY REGULATES | Cytochrome P450 |
| Cytochrome P450 | POSITIVELY REGULATES | Xenobiotic Catabolic Process |
| Xenobiotic Catabolic Process | DECREASES ABUNDANCE OF | Antiviral Agent |
| Antiviral Agent | NEGATIVELY CORRELATED WITH | Human Immunodeficiency Virus Infection |
Comment: Cobicistat does not have any anti-HIV activity on its own; it acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered agents that are metabolized by CYP3A enzymes (https://pubchem.ncbi.nlm.nih.gov/compound/25151504#section=Mechanism-of-Action)
Reference: