Path ID: DB09060_MESH_D059413_4
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C543519 | avibactam | Drug |
| UniProt:P37321 | Extended-spectrum beta-lactamase PER-1 | Protein |
| GO:0008800 | beta-lactamase activity | MolecularActivity |
| taxonomy:287 | Pseudomonas aeruginosa | OrganismTaxon |
| MESH:D059413 | Infectious disease of abdomen | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Avibactam | NEGATIVELY REGULATES | Extended-Spectrum Beta-Lactamase Per-1 |
| Extended-Spectrum Beta-Lactamase Per-1 | POSITIVELY REGULATES | Beta-Lactamase Activity |
| Beta-Lactamase Activity | IN TAXON | Pseudomonas Aeruginosa |
| Pseudomonas Aeruginosa | CAUSES | Infectious Disease Of Abdomen |
Comment: This antibiotic inhbits beta-lactamases, enzymes that break antibiotics and therefore provide resistance to ampicillin and related beta-lacam antibiotics. Avibactam therefore is useful to treat infections caused by bacteria that are multi-resistant to β-lactam antibiotics.
Reference: