Path ID: DB09060_MESH_D059413_3
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C543519 | avibactam | Drug |
| UniProt:P05364 | Beta-lactamase | Protein |
| GO:0008800 | beta-lactamase activity | MolecularActivity |
| taxonomy:550 | Enterobacter cloacae | OrganismTaxon |
| MESH:D059413 | Infectious disease of abdomen | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Avibactam | NEGATIVELY REGULATES | Beta-Lactamase |
| Beta-Lactamase | POSITIVELY REGULATES | Beta-Lactamase Activity |
| Beta-Lactamase Activity | IN TAXON | Enterobacter Cloacae |
| Enterobacter Cloacae | CAUSES | Infectious Disease Of Abdomen |
Comment: This antibiotic inhbits beta-lactamases, enzymes that break antibiotics and therefore provide resistance to ampicillin and related beta-lacam antibiotics. Avibactam therefore is useful to treat infections caused by bacteria that are multi-resistant to β-lactam antibiotics.
Reference: