Path ID: DB09054_MESH_D015451_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C552946 | Idelalisib | Drug |
| UniProt:O00329 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Protein |
| reactome:R-HSA-109704 | PI3K Cascade | Pathway |
| GO:0042100 | B cell proliferation | BiologicalProcess |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Idelalisib | DECREASES ACTIVITY OF | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform |
| Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform | PARTICIPATES IN | Pi3K Cascade |
| Pi3K Cascade | POSITIVELY REGULATES | B Cell Proliferation |
| B Cell Proliferation | POSITIVELY CORRELATED WITH | Leukemia, Lymphocytic, Chronic, B-Cell |
Reference: