Path ID: DB09030_MESH_D020521_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C530299 | vorapaxar | Drug |
| UniProt:P25116 | Proteinase-activated receptor 1 | Protein |
| GO:0015057 | thrombin-activated receptor activity | MolecularActivity |
| reactome:R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | Pathway |
| GO:0070527 | platelet aggregation | BiologicalProcess |
| MESH:D013927 | Thrombosis | PhenotypicFeature |
| MESH:D020521 | Cerebrovascular accident | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Vorapaxar | NEGATIVELY REGULATES | Proteinase-Activated Receptor 1 |
| Proteinase-Activated Receptor 1 | POSITIVELY REGULATES | Thrombin-Activated Receptor Activity |
| Thrombin-Activated Receptor Activity | PARTICIPATES IN | Formation Of Fibrin Clot (Clotting Cascade) |
| Formation Of Fibrin Clot (Clotting Cascade) | POSITIVELY CORRELATED WITH | Platelet Aggregation |
| Platelet Aggregation | POSITIVELY CORRELATED WITH | Thrombosis |
| Thrombosis | POSITIVELY CORRELATED WITH | Cerebrovascular Accident |
Reference: