Path ID: DB09016_MESH_D003866_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C100242 | butriptyline | Drug |
| UniProt:P31645 | Sodium-dependent serotonin transporter | Protein |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051610 | serotonin uptake | BiologicalProcess |
| GO:0051934 | catecholamine uptake involved in synaptic transmission | BiologicalProcess |
| MESH:D003866 | Depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Butriptyline | NEGATIVELY REGULATES | Sodium-Dependent Noradrenaline Transporter |
| Butriptyline | NEGATIVELY REGULATES | Sodium-Dependent Serotonin Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Catecholamine Uptake Involved In Synaptic Transmission |
| Sodium-Dependent Serotonin Transporter | POSITIVELY REGULATES | Serotonin Uptake |
| Serotonin Uptake | POSITIVELY CORRELATED WITH | Depressive Disorder |
| Catecholamine Uptake Involved In Synaptic Transmission | POSITIVELY CORRELATED WITH | Depressive Disorder |
Comment: Butriptyline may seem to be very weak at blocking any biogenic amine uptake, including serotonin (https://pubmed.ncbi.nlm.nih.gov/6499924/).
Reference: