Path ID: DB08980_MESH_D017202_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005275 | fendiline | Drug |
| MESH:D015220 | Calcium Channels | GeneFamily |
| GO:0070509 | calcium ion import | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0033401 | Tissue ischemia | PhenotypicFeature |
| UBERON:0000948 | heart | GrossAnatomicalStructure |
| MESH:D017202 | Ischemic heart disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fendiline | NEGATIVELY REGULATES | Calcium Channels |
| Calcium Channels | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Tissue Ischemia |
| Tissue Ischemia | LOCATED IN | Heart |
| Heart | LOCATION OF | Ischemic Heart Disease |
Comment: Although InterPro and Pfam have entries to encompass different types of calcium channels, the chosen MESH term is the most generic term that encompasses ALL calcium channels, rather than individual domains, subunits or classes.
Reference: