Path ID: DB08949_MESH_D015228_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C005193 | Inositol Niacinate | Drug |
| UniProt:P49019 | Hydroxycarboxylic acid receptor 3 | Protein |
| UniProt:Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Protein |
| reactome:R-HSA-418594 | G alpha (i) signalling events | Pathway |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D015228 | Hypertriglyceridemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Inositol Niacinate | INCREASES ACTIVITY OF | Hydroxycarboxylic Acid Receptor 3 |
| Inositol Niacinate | INCREASES ACTIVITY OF | Hydroxycarboxylic Acid Receptor 2 |
| Hydroxycarboxylic Acid Receptor 3 | PARTICIPATES IN | G Alpha (I) Signalling Events |
| Hydroxycarboxylic Acid Receptor 2 | PARTICIPATES IN | G Alpha (I) Signalling Events |
| G Alpha (I) Signalling Events | DECREASES ABUNDANCE OF | Triglycerides |
| Triglycerides | POSITIVELY CORRELATED WITH | Hypertriglyceridemia |
Comment: Other commonly used names for this drug are inositol nicotinate (CHEBI:50134), myo-inositol hexanicotinate (CHEBI:31699) and inositol hexanicotinate (CHEBI:33064)(https://en.wikipedia.org/wiki/Inositol_nicotinate). This drug is made of niacin (vitamin B3, MESH:D009525) and inositol (MESH:D007294. Note the original drug to curate for this disease was inositol but there is no evidence for it to be used as treatment unless it’s bound to nicotinic acid to form inositol hexanicotinate.
Reference:
- https://go.drugbank.com/drugs/DB08949#mechanism-of-action
- https://en.wikipedia.org/wiki/Hypertriglyceridemia#Treatment
- https://en.wikipedia.org/wiki/Triglyceride#Role_in_disease
- https://pubmed.ncbi.nlm.nih.gov/15083592/
- https://www.sciencedirect.com/science/article/pii/B978032329738700037X
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441126/