Path ID: DB08949_MESH_D010383_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C005193 | Inositol Niacinate | Drug |
| CHEBI:15940 | nicotinic acid | ChemicalSubstance |
| CHEBI:17154 | nicotinamide | ChemicalSubstance |
| HP:0100497 | Vitamin B3 deficiency | PhenotypicFeature |
| MESH:D010383 | Pellagra | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Inositol Niacinate | INCREASES ABUNDANCE OF | Nicotinic Acid |
| Nicotinic Acid | INCREASES ABUNDANCE OF | Nicotinamide |
| Nicotinamide | NEGATIVELY CORRELATED WITH | Vitamin B3 Deficiency |
| Vitamin B3 Deficiency | POSITIVELY CORRELATED WITH | Pellagra |
Comment: Other commonly used names for this drug are inositol nicotinate (CHEBI:50134), myo-inositol hexanicotinate (CHEBI:31699) and inositol hexanicotinate (CHEBI:33064)(https://en.wikipedia.org/wiki/Inositol_nicotinate). This drug is made of niacin (vitamin B3, MESH:D009525) and inositol (MESH:D007294. Note the original drug to curate for this disease was inositol but there is no evidence for it to be used as treatment unless it’s bound to nicotinic acid to form inositol hexanicotinate.
Reference:
- https://go.drugbank.com/drugs/DB08949#mechanism-of-action
- https://pubchem.ncbi.nlm.nih.gov/compound/3720#section=Drug-and-Medication-Information
- https://en.wikipedia.org/wiki/Pellagra#Treatment
- https://en.wikipedia.org/wiki/Nicotinamide
- https://en.wikipedia.org/wiki/Nicotinamide#Niacin_deficiency
- https://onlinelibrary.wiley.com/doi/epdf/10.1002/jppr.1250