Path ID: DB08932_MESH_D000081029_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C533860 | macitentan | Drug |
| UniProt:P25101 | Endothelin-1 receptor | Protein |
| UniProt:P24530 | Endothelin receptor type B | Protein |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| HP:0000822 | Hypertension | PhenotypicFeature |
| MESH:D000081029 | Pulmonary arterial hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Macitentan | DECREASES ACTIVITY OF | Endothelin-1 Receptor |
| Macitentan | DECREASES ACTIVITY OF | Endothelin Receptor Type B |
| Endothelin-1 Receptor | CAPABLE OF | Vasoconstriction |
| Endothelin Receptor Type B | CAPABLE OF | Vasoconstriction |
| Vasoconstriction | HAS PHENOTYPE | Hypertension |
| Hypertension | MANIFESTATION OF | Pulmonary Arterial Hypertension |
Reference: