Path ID: DB08931_MESH_D000081029_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C542595 | riociguat | Drug |
| UniProt:P33402 | Guanylate cyclase soluble subunit alpha-2 | Protein |
| CHEBI:16356 | cyclic guanosine 3’,5’ monophosphate | ChemicalSubstance |
| GO:0038060 | nitric oxide-cGMP-mediated signaling pathway | BiologicalProcess |
| GO:0042311 | vasodilation | BiologicalProcess |
| GO:0060087 | vasular smooth muscle relaxation | BiologicalProcess |
| MESH:D000081029 | Pulmonary arterial hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Riociguat | INCREASES ACTIVITY OF | Guanylate Cyclase Soluble Subunit Alpha-2 |
| Guanylate Cyclase Soluble Subunit Alpha-2 | INCREASES ABUNDANCE OF | Cyclic Guanosine 3’,5’ Monophosphate |
| Cyclic Guanosine 3’,5’ Monophosphate | PARTICIPATES IN | Nitric Oxide-Cgmp-Mediated Signaling Pathway |
| Nitric Oxide-Cgmp-Mediated Signaling Pathway | CONTRIBUTES TO | Vasodilation |
| Vasodilation | CONTRIBUTES TO | Vasular Smooth Muscle Relaxation |
| Vasular Smooth Muscle Relaxation | PREVENTS | Pulmonary Arterial Hypertension |
Reference: