Path ID: DB08910_MESH_D009101_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C467566 | Pomalidomide | Drug |
| CL:0000623 | Natural killer cell | Cell |
| GO:0002423 | Natural killer cell mediated immune response to tumor cell | BiologicalProcess |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| UniProt:P01375 | Tumor necrosis factor | Protein |
| reactome:R-HSA-75893 | TNF signaling | Pathway |
| CL:0000092 | Osteoclast | Cell |
| GO:0045453 | Bone resorption | BiologicalProcess |
| GO:0010573 | Vascular endothelial growth factor production | BiologicalProcess |
| GO:0001525 | Angiogenesis | BiologicalProcess |
| InterPro:IPR001321 | Hypoxia-inducible factor-1 alpha | GeneFamily |
| MESH:D009101 | Multiple myeloma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pomalidomide | POSITIVELY REGULATES | Natural Killer Cell |
| Natural Killer Cell | POSITIVELY REGULATES | Natural Killer Cell Mediated Immune Response To Tumor Cell |
| Natural Killer Cell Mediated Immune Response To Tumor Cell | NEGATIVELY CORRELATED WITH | Multiple Myeloma |
| Pomalidomide | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 2 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Pomalidomide | DECREASES ACTIVITY OF | Tumor Necrosis Factor |
| Tumor Necrosis Factor | PARTICIPATES IN | Tnf Signaling |
| Tnf Signaling | POSITIVELY REGULATES | Inflammatory Response |
| Pomalidomide | NEGATIVELY REGULATES | Osteoclast |
| Osteoclast | POSITIVELY REGULATES | Bone Resorption |
| Bone Resorption | OCCURS IN | Multiple Myeloma |
| Pomalidomide | NEGATIVELY REGULATES | Vascular Endothelial Growth Factor Production |
| Vascular Endothelial Growth Factor Production | POSITIVELY REGULATES | Angiogenesis |
| Pomalidomide | NEGATIVELY REGULATES | Hypoxia-Inducible Factor-1 Alpha |
| Hypoxia-Inducible Factor-1 Alpha | POSITIVELY REGULATES | Angiogenesis |
| Angiogenesis | POSITIVELY CORRELATED WITH | Multiple Myeloma |
Reference: