Path ID: DB08908_MESH_D020529_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069462 | Dimethyl fumarate | Drug |
| reactome:R-HSA-8932339 | ROS sensing by NFE2L2 | Pathway |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| MESH:D020529 | Relapsing remitting multiple sclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dimethyl Fumarate | POSITIVELY REGULATES | Ros Sensing By Nfe2L2 |
| Ros Sensing By Nfe2L2 | NEGATIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
Comment: Dimethyl fumarate ia a prodrug which is metabolised into the pharmacologically active monomethyl fumarate. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood.
Reference: