Path ID: DB08908_MESH_D011565_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB08908 | Dimethyl fumarate | Drug |
| GO:0038061 | NIK/NF-kappaB signaling | BiologicalProcess |
| GO:0001816 | Cytokine production | BiologicalProcess |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| reactome:R-HSA-8932339 | ROS sensing by NFE2L2 | Pathway |
| UniProt:P09601 | Heme oxygenase 1 | Protein |
| UniProt:Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Protein |
| GO:1990266 | Neutrophil migration | BiologicalProcess |
| MESH:D011565 | Psoriasis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dimethyl Fumarate | NEGATIVELY REGULATES | Nik/Nf-Kappab Signaling |
| Nik/Nf-Kappab Signaling | POSITIVELY REGULATES | Cytokine Production |
| Cytokine Production | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Dimethyl Fumarate | POSITIVELY REGULATES | Ros Sensing By Nfe2L2 |
| Ros Sensing By Nfe2L2 | INCREASES ACTIVITY OF | Heme Oxygenase 1 |
| Heme Oxygenase 1 | NEGATIVELY REGULATES | Inflammatory Response |
| Dimethyl Fumarate | INCREASES ACTIVITY OF | Hydroxycarboxylic Acid Receptor 2 |
| Hydroxycarboxylic Acid Receptor 2 | NEGATIVELY REGULATES | Neutrophil Migration |
| Neutrophil Migration | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | CAUSES | Psoriasis |
Comment: Fumaric acid is used for the treatment of psoriasis in an ester form as dimethyl fumarate. This graph was made for dimethyl fumarate. Dimethyl fumarate ia a prodrug which is metabolised into the pharmacologically active monomethyl fumarate.
Reference: