Path ID: DB08906_MESH_D001249_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C523187 | Fluticasone furoate | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| UniProt:P04083 | Annexin A1 | Protein |
| UniProt:P47712 | Cytosolic phospholipase A2 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| MESH:D017998 | Leukotriene D4 | ChemicalSubstance |
| GO:0006939 | Smooth muscle contraction | BiologicalProcess |
| GO:0043117 | Positive regulation of vascular permeability | BiologicalProcess |
| MESH:D001249 | Asthma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fluticasone Furoate | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Glucocorticoid Receptor | INCREASES ACTIVITY OF | Annexin A1 |
| Annexin A1 | DECREASES ACTIVITY OF | Cytosolic Phospholipase A2 |
| Annexin A1 | NEGATIVELY REGULATES | Prostaglandin G/H Synthase 2 |
| Cytosolic Phospholipase A2 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandin G/H Synthase 2 | INCREASES ABUNDANCE OF | Prostaglandins |
| Cytosolic Phospholipase A2 | INCREASES ABUNDANCE OF | Leukotriene D4 |
| Leukotriene D4 | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Leukotriene D4 | POSITIVELY REGULATES | Positive Regulation Of Vascular Permeability |
| Leukotriene D4 | POSITIVELY REGULATES | Inflammatory Response |
| Positive Regulation Of Vascular Permeability | MANIFESTATION OF | Asthma |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Asthma |
| Prostaglandins | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Smooth Muscle Contraction | MANIFESTATION OF | Asthma |
Reference: