Path ID: DB08904_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068582 | Certolizumab pegol | Drug |
| UniProt:P01375 | Tumor necrosis factor | Protein |
| reactome:R-HSA-75893 | TNF signaling | Pathway |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0002829 | Arthralgia | PhenotypicFeature |
| HP:0001386 | Joint swelling | PhenotypicFeature |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Certolizumab Pegol | DECREASES ACTIVITY OF | Tumor Necrosis Factor |
| Tumor Necrosis Factor | PARTICIPATES IN | Tnf Signaling |
| Tnf Signaling | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY REGULATES | Joint Swelling |
| Inflammatory Response | POSITIVELY REGULATES | Arthralgia |
| Arthralgia | MANIFESTATION OF | Rheumatoid Arthritis |
| Joint Swelling | MANIFESTATION OF | Rheumatoid Arthritis |
| Inflammatory Response | CAUSES | Rheumatoid Arthritis |
Reference: