Path ID: DB08901_MESH_D015464_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004103 | ponatinib | Drug |
| UniProt:P00519 | Tyrosine-protein kinase ABL1 | Protein |
| MESH:D016044 | Fusion Proteins, bcr-abl | Protein |
| GO:0004674 | protein serine/threonine kinase activity | MolecularActivity |
| GO:0007266 | Rho protein signal transduction | BiologicalProcess |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| GO:0006915 | apoptotic process | BiologicalProcess |
| MESH:D015464 | Chronic myeloid leukemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ponatinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Abl1 |
| Tyrosine-Protein Kinase Abl1 | PARTICIPATES IN | Fusion Proteins, Bcr-Abl |
| Fusion Proteins, Bcr-Abl | POSITIVELY REGULATES | Protein Serine/Threonine Kinase Activity |
| Protein Serine/Threonine Kinase Activity | POSITIVELY CORRELATED WITH | Rho Protein Signal Transduction |
| Rho Protein Signal Transduction | POSITIVELY CORRELATED WITH | Cell Population Proliferation |
| Rho Protein Signal Transduction | NEGATIVELY CORRELATED WITH | Apoptotic Process |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Chronic Myeloid Leukemia |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Chronic Myeloid Leukemia |
Reference: