Path ID: DB08895_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C479163 | Tofacitinib | Drug |
| UniProt:P23458 | Tyrosine-protein kinase JAK1 | Protein |
| UniProt:P52333 | Tyrosine-protein kinase JAK3 | Protein |
| GO:0007259 | Receptor signaling pathway via JAK-STAT | BiologicalProcess |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| InterPro:IPR000975 | Interleukin-1 family | GeneFamily |
| UniProt:P05231 | Interleukin-6 | Protein |
| GO:0032640 | BiologicalProcess | BiologicalProcess |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tofacitinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Jak1 |
| Tyrosine-Protein Kinase Jak1 | POSITIVELY REGULATES | Receptor Signaling Pathway Via Jak-Stat |
| Tofacitinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Jak3 |
| Tyrosine-Protein Kinase Jak3 | POSITIVELY REGULATES | Receptor Signaling Pathway Via Jak-Stat |
| Receptor Signaling Pathway Via Jak-Stat | PARTICIPATES IN | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Interleukin-1 Family |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Interleukin-6 |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Biologicalprocess |
| Interleukin-1 Family | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
| Interleukin-6 | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
| Biologicalprocess | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
Reference: