Path ID: DB08890_MESH_D043183_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C523483 | linaclotide | Drug |
| UniProt:P25092 | Heat-stable enterotoxin receptor | Protein |
| GO:0006182 | cGMP biosynthetic process | BiologicalProcess |
| GO:0015701 | bicarbonate transport | BiologicalProcess |
| GO:0006821 | chloride transport | BiologicalProcess |
| GO:0006833 | water transport | BiologicalProcess |
| MESH:D007419 | Intestinal Secretions | ChemicalSubstance |
| GO:0120054 | intestinal motility | BiologicalProcess |
| UBERON:0001800 | sensory ganglion | GrossAnatomicalStructure |
| UBERON:0025525 | motor system | GrossAnatomicalStructure |
| HP:0030895 | Abnormal gastrointestinal motility | PhenotypicFeature |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D043183 | Irritable bowel syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Linaclotide | POSITIVELY REGULATES | Heat-Stable Enterotoxin Receptor |
| Heat-Stable Enterotoxin Receptor | POSITIVELY REGULATES | Cgmp Biosynthetic Process |
| Cgmp Biosynthetic Process | INCREASES ACTIVITY OF | Motor System |
| Motor System | NEGATIVELY CORRELATED WITH | Abnormal Gastrointestinal Motility |
| Cgmp Biosynthetic Process | DECREASES ACTIVITY OF | Sensory Ganglion |
| Sensory Ganglion | POSITIVELY CORRELATED WITH | Pain |
| Abnormal Gastrointestinal Motility | MANIFESTATION OF | Irritable Bowel Syndrome |
| Pain | MANIFESTATION OF | Irritable Bowel Syndrome |
| Cgmp Biosynthetic Process | POSITIVELY CORRELATED WITH | Bicarbonate Transport |
| Cgmp Biosynthetic Process | POSITIVELY CORRELATED WITH | Chloride Transport |
| Cgmp Biosynthetic Process | POSITIVELY CORRELATED WITH | Water Transport |
| Bicarbonate Transport | POSITIVELY CORRELATED WITH | Intestinal Secretions |
| Chloride Transport | POSITIVELY CORRELATED WITH | Intestinal Secretions |
| Water Transport | POSITIVELY CORRELATED WITH | Intestinal Secretions |
| Bicarbonate Transport | POSITIVELY CORRELATED WITH | Intestinal Motility |
| Chloride Transport | POSITIVELY CORRELATED WITH | Intestinal Motility |
| Water Transport | POSITIVELY CORRELATED WITH | Intestinal Motility |
| Intestinal Motility | NEGATIVELY CORRELATED WITH | Irritable Bowel Syndrome |
| Intestinal Secretions | NEGATIVELY CORRELATED WITH | Irritable Bowel Syndrome |
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