Path ID: DB08889_MESH_D009101_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB08889 | carfilzomib | Drug |
| UniProt:P28074 | Proteasome subunit beta type-5 | Protein |
| UniProt:P28062 | Proteasome subunit beta type-8 | Protein |
| UniProt:P20618 | Proteasome subunit beta type-1 | Protein |
| UniProt:P28065 | Proteasome subunit beta type-9 | Protein |
| UniProt:P49721 | Proteasome subunit beta type-2 | Protein |
| UniProt:P40306 | Proteasome subunit beta type-10 | Protein |
| GO:0005839 | proteosome core complex | CellularComponent |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| CL:0001063 | tumor cell | Cell |
| MESH:D009101 | Multiple myeloma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Carfilzomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-5 |
| Carfilzomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-8 |
| Carfilzomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-1 |
| Carfilzomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-9 |
| Carfilzomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-2 |
| Carfilzomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-10 |
| Proteasome Subunit Beta Type-5 | LOCATED IN | Proteosome Core Complex |
| Proteasome Subunit Beta Type-8 | LOCATED IN | Proteosome Core Complex |
| Proteasome Subunit Beta Type-1 | LOCATED IN | Proteosome Core Complex |
| Proteasome Subunit Beta Type-9 | LOCATED IN | Proteosome Core Complex |
| Proteasome Subunit Beta Type-2 | LOCATED IN | Proteosome Core Complex |
| Proteasome Subunit Beta Type-10 | LOCATED IN | Proteosome Core Complex |
| Proteosome Core Complex | POSITIVELY CORRELATED WITH | Cell Population Proliferation |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Tumor Cell |
| Tumor Cell | POSITIVELY CORRELATED WITH | Multiple Myeloma |
Reference: