Path ID: DB08887_MESH_D015228_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB08887 | Icosapent ethyl | Drug |
| GO:0006635 | fatty acid beta-oxidation | BiologicalProcess |
| GO:0008610 | lipid biosynthetic process | BiologicalProcess |
| UniProt:O75907 | Diacylglycerol O-acyltransferase 1 | Protein |
| UniProt:P06858 | Lipoprotein lipase | Protein |
| GO:0019915 | lipid storage | BiologicalProcess |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D015228 | Hypertriglyceridemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Icosapent Ethyl | POSITIVELY REGULATES | Fatty Acid Beta-Oxidation |
| Icosapent Ethyl | NEGATIVELY REGULATES | Lipid Biosynthetic Process |
| Icosapent Ethyl | DECREASES ACTIVITY OF | Diacylglycerol O-Acyltransferase 1 |
| Icosapent Ethyl | INCREASES ACTIVITY OF | Lipoprotein Lipase |
| Fatty Acid Beta-Oxidation | NEGATIVELY CORRELATED WITH | Lipid Storage |
| Lipid Biosynthetic Process | POSITIVELY CORRELATED WITH | Lipid Storage |
| Diacylglycerol O-Acyltransferase 1 | POSITIVELY REGULATES | Lipid Storage |
| Lipoprotein Lipase | NEGATIVELY REGULATES | Lipid Storage |
| Lipid Storage | POSITIVELY CORRELATED WITH | Triglycerides |
| Triglycerides | POSITIVELY CORRELATED WITH | Hypertriglyceridemia |
Comment: Icosapent ethyl is an ethyl ester of eicosapentaenoic acid, which is used to treat hypertriglyceridemia.
Reference: