Path ID: DB08880_MESH_D009103_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C527525 | teriflunomide | Drug |
| UniProt:Q02127 | Dihydroorotate dehydrogenase (quinone), mitochondrial | Protein |
| GO:0006221 | pyrimidine nucleotide biosynthetic process | BiologicalProcess |
| GO:0050671 | positive regulation of lymphocyte proliferation | BiologicalProcess |
| UBERON:0001017 | central nervous system | GrossAnatomicalStructure |
| GO:0006954 | inflammatory response | BiologicalProcess |
| GO:0048681 | negative regulation of axon regeneration | BiologicalProcess |
| MESH:D009103 | Multiple sclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Teriflunomide | NEGATIVELY REGULATES | Dihydroorotate Dehydrogenase (Quinone), Mitochondrial |
| Dihydroorotate Dehydrogenase (Quinone), Mitochondrial | POSITIVELY REGULATES | Pyrimidine Nucleotide Biosynthetic Process |
| Pyrimidine Nucleotide Biosynthetic Process | PARTICIPATES IN | Positive Regulation Of Lymphocyte Proliferation |
| Positive Regulation Of Lymphocyte Proliferation | LOCATED IN | Central Nervous System |
| Central Nervous System | AFFECTED BY | Inflammatory Response |
| Inflammatory Response | CONTRIBUTES TO | Negative Regulation Of Axon Regeneration |
| Negative Regulation Of Axon Regeneration | CONTRIBUTES TO | Multiple Sclerosis |
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