Path ID: DB08877_MESH_D011087_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C540383 | Ruxolitinib | Drug |
| UniProt:O60674 | Tyrosine-protein kinase JAK2 | Protein |
| UniProt:P23458 | Tyrosine-protein kinase JAK1 | Protein |
| GO:0007259 | Receptor signaling pathway via JAK-STAT | BiologicalProcess |
| GO:0070102 | Interleukin-6-mediated signaling pathway | BiologicalProcess |
| GO:0019221 | Cytokine-mediated signaling pathway | BiologicalProcess |
| GO:0008283 | Cell population proliferation | BiologicalProcess |
| MESH:D011087 | Polycythemia vera | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ruxolitinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Jak2 |
| Ruxolitinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Jak1 |
| Tyrosine-Protein Kinase Jak2 | POSITIVELY REGULATES | Receptor Signaling Pathway Via Jak-Stat |
| Tyrosine-Protein Kinase Jak1 | POSITIVELY REGULATES | Receptor Signaling Pathway Via Jak-Stat |
| Receptor Signaling Pathway Via Jak-Stat | POSITIVELY REGULATES | Interleukin-6-Mediated Signaling Pathway |
| Receptor Signaling Pathway Via Jak-Stat | POSITIVELY REGULATES | Cytokine-Mediated Signaling Pathway |
| Receptor Signaling Pathway Via Jak-Stat | POSITIVELY REGULATES | Cell Population Proliferation |
| Interleukin-6-Mediated Signaling Pathway | POSITIVELY CORRELATED WITH | Polycythemia Vera |
| Cytokine-Mediated Signaling Pathway | POSITIVELY CORRELATED WITH | Polycythemia Vera |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Polycythemia Vera |
Reference: