Path ID: DB08875_MESH_C536914_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C558660 | Cabozantinib | Drug |
| UniProt:P08581 | Hepatocyte growth factor receptor | Protein |
| UniProt:P35968 | Vascular endothelial growth factor receptor 2 | Protein |
| UniProt:P07949 | Proto-oncogene tyrosine-protein kinase receptor Ret | Protein |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | BiologicalProcess |
| GO:0001525 | Angiogenesis | BiologicalProcess |
| HP:0031377 | Abnormal cell proliferation | PhenotypicFeature |
| MESH:C536914 | Medullary thyroid carcinoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cabozantinib | DECREASES ACTIVITY OF | Hepatocyte Growth Factor Receptor |
| Cabozantinib | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor Receptor 2 |
| Cabozantinib | DECREASES ACTIVITY OF | Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret |
| Hepatocyte Growth Factor Receptor | POSITIVELY REGULATES | Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway |
| Vascular Endothelial Growth Factor Receptor 2 | POSITIVELY REGULATES | Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway |
| Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret | POSITIVELY REGULATES | Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway |
| Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway | POSITIVELY CORRELATED WITH | Angiogenesis |
| Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway | POSITIVELY CORRELATED WITH | Abnormal Cell Proliferation |
| Angiogenesis | OCCURS IN | Medullary Thyroid Carcinoma |
| Abnormal Cell Proliferation | OCCURS IN | Medullary Thyroid Carcinoma |
Reference: