Path ID: DB08872_MESH_D012148_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C493250 | Gabapentin enacarbil | Drug |
| CHEBI:42797 | Gabapentin | ChemicalSubstance |
| UniProt:Q9NY47 | Voltage-dependent calcium channel subunit alpha-2/delta-2 | Protein |
| GO:0098793 | Presynapse | CellularComponent |
| GO:0070509 | Calcium ion import | BiologicalProcess |
| GO:0007269 | Neurotransmitter release | BiologicalProcess |
| HP:0012514 | Lower limb pain | PhenotypicFeature |
| MESH:D012148 | Restless legs | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Gabapentin Enacarbil | HAS METABOLITE | Gabapentin |
| Gabapentin | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 |
| Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 | LOCATED IN | Presynapse |
| Presynapse | PARTICIPATES IN | Calcium Ion Import |
| Calcium Ion Import | PARTICIPATES IN | Neurotransmitter Release |
| Neurotransmitter Release | PARTICIPATES IN | Lower Limb Pain |
| Lower Limb Pain | CORRELATED WITH | Restless Legs |
Comment: gabapentin enacarbil is a prodrug of gabapentin, it’s physiological effects are the same as gabapentin
Reference: