Path ID: DB08871_MESH_D008080_1

Concepts
Identifier | Name | Type |
---|---|---|
MESH:C490954 | eribulin | Drug |
PR:000028799 | Tubulin | MacromolecularComplex |
GO:0000278 | mitotic cell cycle | BiologicalProcess |
GO:0051225 | spindle assembly | BiologicalProcess |
GO:0006915 | apoptotic process | BiologicalProcess |
MESH:D008080 | Liposarcoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
Subject | Predicate | Object |
---|---|---|
Eribulin | NEGATIVELY REGULATES | Tubulin |
Tubulin | POSITIVELY REGULATES | Mitotic Cell Cycle |
Tubulin | POSITIVELY REGULATES | Spindle Assembly |
Mitotic Cell Cycle | NEGATIVELY CORRELATED WITH | Apoptotic Process |
Spindle Assembly | NEGATIVELY CORRELATED WITH | Apoptotic Process |
Apoptotic Process | POSITIVELY CORRELATED WITH | Liposarcoma |
Reference:
- https://alpha.targetvalidation.org/drug/CHEMBL1683590
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1683590/
- https://en.wikipedia.org/wiki/Eribulin#Structure_and_mechanism
- https://en.wikipedia.org/wiki/Microtubule#Tubulin-binding_drugs_and_chemical_effects
- https://go.drugbank.com/drugs/DB08871#mechanism-of-action