Path ID: DB08842_MESH_D000544_1

db08842-mesh-d000544-1

Concepts

Identifier Name Type
MESH:D000108 Acetylcarnitine Drug
GO:0007271 synaptic transmission, cholinergic BiologicalProcess
GO:0035249 synaptic transmission, glutamatergic BiologicalProcess
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex CellularComponent
GO:0004129 cytochrome-c oxidase activity MolecularActivity
MESH:D005609 Free Radicals ChemicalSubstance
MESH:D017475 Receptors, Nerve Growth Factor ChemicalSubstance
GO:0018393 internal peptidyl-lysine acetylation BiologicalProcess
GO:0006979 response to oxidative stress BiologicalProcess
HP:0025464 Increased reactive oxygen species production PhenotypicFeature
GO:0007613 memory BiologicalProcess
CHEBI:64645 amyloid-β ChemicalSubstance
InterPro:IPR002955 Microtubule-associated protein Tau GeneFamily
GO:0014055 acetylcholine secretion, neurotransmission BiologicalProcess
GO:0061535 glutamate secretion, neurotransmission BiologicalProcess
GO:0150076 neuroinflammatory response BiologicalProcess
HP:0002354 Memory impairment PhenotypicFeature
CHEBI:60425 amyloid fibril ChemicalSubstance
HP:0002185 Neurofibrillary tangles PhenotypicFeature
MESH:D000544 Alzheimer Disease Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Acetylcarnitine POSITIVELY REGULATES Synaptic Transmission, Cholinergic
Acetylcarnitine POSITIVELY REGULATES Synaptic Transmission, Glutamatergic
Acetylcarnitine INCREASES ACTIVITY OF Mitochondrial Alpha-Ketoglutarate Dehydrogenase Complex
Acetylcarnitine INCREASES ACTIVITY OF Cytochrome-C Oxidase Activity
Acetylcarnitine DECREASES ABUNDANCE OF Free Radicals
Acetylcarnitine INCREASES ABUNDANCE OF Receptors, Nerve Growth Factor
Acetylcarnitine POSITIVELY REGULATES Internal Peptidyl-Lysine Acetylation
Synaptic Transmission, Cholinergic POSITIVELY CORRELATED WITH Acetylcholine Secretion, Neurotransmission
Synaptic Transmission, Glutamatergic POSITIVELY CORRELATED WITH Glutamate Secretion, Neurotransmission
Mitochondrial Alpha-Ketoglutarate Dehydrogenase Complex POSITIVELY REGULATES Response To Oxidative Stress
Cytochrome-C Oxidase Activity POSITIVELY REGULATES Response To Oxidative Stress
Free Radicals POSITIVELY CORRELATED WITH Increased Reactive Oxygen Species Production
Receptors, Nerve Growth Factor POSITIVELY CORRELATED WITH Memory
Internal Peptidyl-Lysine Acetylation OCCURS IN Amyloid-Β
Internal Peptidyl-Lysine Acetylation OCCURS IN Microtubule-Associated Protein Tau
Response To Oxidative Stress CORRELATED WITH Neuroinflammatory Response
Increased Reactive Oxygen Species Production POSITIVELY CORRELATED WITH Neuroinflammatory Response
Memory NEGATIVELY CORRELATED WITH Memory Impairment
Amyloid-Β CONTRIBUTES TO Amyloid Fibril
Microtubule-Associated Protein Tau CONTRIBUTES TO Neurofibrillary Tangles
Acetylcholine Secretion, Neurotransmission NEGATIVELY CORRELATED WITH Alzheimer Disease
Glutamate Secretion, Neurotransmission NEGATIVELY CORRELATED WITH Alzheimer Disease
Neuroinflammatory Response POSITIVELY CORRELATED WITH Alzheimer Disease
Memory Impairment POSITIVELY CORRELATED WITH Alzheimer Disease
Amyloid Fibril POSITIVELY CORRELATED WITH Alzheimer Disease
Neurofibrillary Tangles POSITIVELY CORRELATED WITH Alzheimer Disease

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