Path ID: DB08820_MESH_D003550_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C545203 | Ivacaftor | Drug |
| UniProt:P13569 | Cystic fibrosis transmembrane conductance regulator | Protein |
| MESH:D003550 | Cystic fibrosis of the lung | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ivacaftor | INCREASES ACTIVITY OF | Cystic Fibrosis Transmembrane Conductance Regulator |
| Cystic Fibrosis Transmembrane Conductance Regulator | DISRUPTED BY | Cystic Fibrosis Of The Lung |
Comment: Ivacaftor as monotherapy has failed to show a benefit for patients with delta-F508 mutations
Reference: