Path ID: DB08162_MESH_D020301_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C049347 | fasudil | Drug |
| DB:DB04707 | Hydroxyfasudil | ChemicalSubstance |
| UniProt:Q13464 | Rho-associated protein kinase 1 | Protein |
| GO:0014829 | vascular associated smooth muscle contraction | BiologicalProcess |
| MESH:D020301 | Spasm of cerebral arteries | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fasudil | HAS METABOLITE | Hydroxyfasudil |
| Hydroxyfasudil | DECREASES ACTIVITY OF | Rho-Associated Protein Kinase 1 |
| Rho-Associated Protein Kinase 1 | POSITIVELY REGULATES | Vascular Associated Smooth Muscle Contraction |
| Vascular Associated Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Spasm Of Cerebral Arteries |
Reference: