Path ID: DB07615_MESH_D003876_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C012293 | Tranilast | Drug |
| UniProt:P35354 | Cyclooxygenase-2 | Protein |
| GO:0001516 | Prostaglandin biosynthetic process | BiologicalProcess |
| MESH:D016207 | Cytokines release | BiologicalProcess |
| MESH:D044062 | Prostaglandins I | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| MESH:D003876 | Atopic dermatitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tranilast | DECREASES ACTIVITY OF | Cyclooxygenase-2 |
| Cyclooxygenase-2 | DECREASES ACTIVITY OF | Prostaglandin Biosynthetic Process |
| Prostaglandin Biosynthetic Process | DECREASES ABUNDANCE OF | Prostaglandins I |
| Tranilast | DECREASES ACTIVITY OF | Cytokines Release |
| Cytokines Release | AMELIORATES | Inflammatory Response |
| Prostaglandins I | AMELIORATES | Inflammatory Response |
| Inflammatory Response | CORRELATED WITH | Atopic Dermatitis |
Reference: