Path ID: DB06824_MESH_D002292_3
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014266 | Trientine | Drug |
| MESH:D003300 | Copper | ChemicalSubstance |
| MESH:D017382 | Reactive Oxygen Species | ChemicalSubstance |
| reactome:R-HSA-6802957 | Oncogenic MAPK signaling | Pathway |
| GO:0012501 | programmed cell death | BiologicalProcess |
| CL:0001063 | neoplastic cell | Cell |
| MESH:D002292 | Carcinoma, Renal Cell | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trientine | DISRUPTS | Copper |
| Trientine | NEGATIVELY REGULATES | Oncogenic Mapk Signaling |
| Oncogenic Mapk Signaling | POSITIVELY REGULATES | Programmed Cell Death |
| Copper | INCREASES ACTIVITY OF | Reactive Oxygen Species |
| Reactive Oxygen Species | POSITIVELY REGULATES | Programmed Cell Death |
| Programmed Cell Death | OCCURS IN | Neoplastic Cell |
| Neoplastic Cell | CAUSES | Carcinoma, Renal Cell |
Reference: