Path ID: DB06824_MESH_D002292_2

db06824-mesh-d002292-2

Concepts

Identifier Name Type
MESH:D014266 Trientine Drug
MESH:D003300 Copper ChemicalSubstance
UniProt:P17948 Vascular endothelial growth factor receptor 1 Protein
UniProt:P05230 Fibroblast growth factor 1 Protein
UniProt:P19838 Nuclear factor NF-kappa-B p105 subunit Protein
UniProt:P10145 Interleukin-8 Protein
InterPro:IPR000975 Interleukin-1 family GeneFamily
InterPro:IPR003574 Interleukin-6 GeneFamily
GO:0001525 angiogenesis BiologicalProcess
CL:0001063 neoplastic cell Cell
MESH:D002292 Carcinoma, Renal Cell Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Trientine DISRUPTS Copper
Copper POSITIVELY CORRELATED WITH Vascular Endothelial Growth Factor Receptor 1
Copper POSITIVELY CORRELATED WITH Fibroblast Growth Factor 1
Copper POSITIVELY CORRELATED WITH Nuclear Factor Nf-Kappa-B P105 Subunit
Copper POSITIVELY CORRELATED WITH Interleukin-8
Copper POSITIVELY CORRELATED WITH Interleukin-1 Family
Copper POSITIVELY CORRELATED WITH Interleukin-6
Vascular Endothelial Growth Factor Receptor 1 POSITIVELY REGULATES Angiogenesis
Fibroblast Growth Factor 1 POSITIVELY REGULATES Angiogenesis
Nuclear Factor Nf-Kappa-B P105 Subunit POSITIVELY REGULATES Angiogenesis
Interleukin-8 POSITIVELY REGULATES Angiogenesis
Interleukin-1 Family POSITIVELY REGULATES Angiogenesis
Interleukin-6 POSITIVELY REGULATES Angiogenesis
Angiogenesis OCCURS IN Neoplastic Cell
Neoplastic Cell CAUSES Carcinoma, Renal Cell

Reference: