Path ID: DB06813_MESH_D016411_1

db06813-mesh-d016411-1

Concepts

Identifier Name Type
MESH:C418863 pralatrexate Drug
UniProt:P00374 Dihydrofolate reductase Protein
UniProt:P04818 Thymidylate synthase Protein
GO:0006221 pyrimidine nucleotide biosynthetic process BiologicalProcess
GO:0046654 tetrahydrofolate biosynthetic process BiologicalProcess
GO:0042098 T cell proliferation BiologicalProcess
MESH:D016411 Peripheral T-cell lymphoma Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Pralatrexate DECREASES ACTIVITY OF Dihydrofolate Reductase
Pralatrexate DECREASES ACTIVITY OF Thymidylate Synthase
Thymidylate Synthase POSITIVELY REGULATES Pyrimidine Nucleotide Biosynthetic Process
Dihydrofolate Reductase POSITIVELY REGULATES Tetrahydrofolate Biosynthetic Process
Tetrahydrofolate Biosynthetic Process POSITIVELY CORRELATED WITH T Cell Proliferation
Pyrimidine Nucleotide Biosynthetic Process POSITIVELY CORRELATED WITH T Cell Proliferation
T Cell Proliferation POSITIVELY CORRELATED WITH Peripheral T-Cell Lymphoma

Reference: