Path ID: DB06710_MESH_D019584_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008777 | methyltestosterone | Drug |
| UniProt:P10275 | Androgen receptor | Protein |
| CHEBI:34179 | 17alpha-Methylestradiol | Drug |
| UniProt:P03372 | Estrogen receptor | Protein |
| MESH:D014666 | Vasomotor System | GrossAnatomicalStructure |
| GO:0097746 | blood vessel diameter maintenance | BiologicalProcess |
| GO:0006874 | cellular calcium ion homeostasis | BiologicalProcess |
| GO:0001659 | temperature homeostasis | BiologicalProcess |
| HP:0005968 | Temperature instability | PhenotypicFeature |
| MESH:D019584 | Menopausal Flushing | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Methyltestosterone | INCREASES ACTIVITY OF | Androgen Receptor |
| Methyltestosterone | PRECEDES | 17Alpha-Methylestradiol |
| 17Alpha-Methylestradiol | INCREASES ACTIVITY OF | Estrogen Receptor |
| Estrogen Receptor | POSITIVELY REGULATES | Cellular Calcium Ion Homeostasis |
| Androgen Receptor | CORRELATED WITH | Blood Vessel Diameter Maintenance |
| Blood Vessel Diameter Maintenance | CORRELATED WITH | Vasomotor System |
| Cellular Calcium Ion Homeostasis | REGULATES | Vasomotor System |
| Vasomotor System | POSITIVELY REGULATES | Temperature Homeostasis |
| Temperature Homeostasis | NEGATIVELY CORRELATED WITH | Temperature Instability |
| Temperature Instability | POSITIVELY CORRELATED WITH | Menopausal Flushing |
Comment: The disease is denoted Menopausal flushing in the original file but Hot flashes in MESH. The etiology of hot flashes has yet to be determined (https://pubmed.ncbi.nlm.nih.gov/15065632/).
Reference: