Path ID: DB06708_MESH_D016778_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C102070 | lumefantrine | Drug |
| UniProt:Q8IL04 | Heme ligase | Protein |
| GO:0042167 | heme catabolic process | BiologicalProcess |
| MESH:D006418 | Heme | ChemicalSubstance |
| taxonomy:5833 | Plasmodium falciparum | OrganismTaxon |
| MESH:D016778 | Falciparum malaria | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lumefantrine | NEGATIVELY REGULATES | Heme Ligase |
| Heme Ligase | POSITIVELY CORRELATED WITH | Heme Catabolic Process |
| Heme Catabolic Process | DECREASES ABUNDANCE OF | Heme |
| Heme | DISRUPTS | Plasmodium Falciparum |
| Plasmodium Falciparum | CAUSES | Falciparum Malaria |
Comment: exact MoA is unknown
Reference: