Path ID: DB06684_MESH_D003865_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069503 | vilazodone | Drug |
| UniProt:P08908 | 5-hydroxytryptamine receptor 1A | Protein |
| GO:0060096 | serotonin secretion, neurotransmission | BiologicalProcess |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Vilazodone | POSITIVELY REGULATES | 5-Hydroxytryptamine Receptor 1A |
| 5-Hydroxytryptamine Receptor 1A | POSITIVELY REGULATES | Serotonin Secretion, Neurotransmission |
| Serotonin Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Major Depressive Disorder |
Comment: this drug is a partial agonist at postsynaptic 5-HT1A receptors (https://en.wikipedia.org/wiki/5-HT1A_receptor#Partial_agonists) and are sometimes used in low doses as augmentation to SSRIs (https://en.wikipedia.org/wiki/5-HT1A_receptor#Neuromodulation).
Reference:
- https://go.drugbank.com/drugs/DB06684#mechanism-of-action
- https://go.drugbank.com/drugs/DB06684#BE0000291
- https://en.wikipedia.org/wiki/5-HT1A_receptor
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841022/
- https://en.wikipedia.org/wiki/5-HT1A_receptor#cite_note-pmid2883013-21
- https://pubmed.ncbi.nlm.nih.gov/12559651/