Path ID: DB06663_MESH_D000308_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C517782 | pasireotide | Drug |
| UniProt:P30872 | Somatostatin receptor type 1 | Protein |
| UniProt:P30874 | Somatostatin receptor type 2 | Protein |
| UniProt:P32745 | Somatostatin receptor type 3 | Protein |
| UniProt:P35346 | Somatostatin receptor type 5 | Protein |
| GO:0051460 | negative regulation of corticotropin secretion | BiologicalProcess |
| GO:0051463 | negative regulation of cortisol secretion | BiologicalProcess |
| CHEBI:17650 | cortisol | ChemicalSubstance |
| MESH:D000308 | Hypercortisolism | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pasireotide | INCREASES ACTIVITY OF | Somatostatin Receptor Type 1 |
| Pasireotide | INCREASES ACTIVITY OF | Somatostatin Receptor Type 2 |
| Pasireotide | INCREASES ACTIVITY OF | Somatostatin Receptor Type 3 |
| Pasireotide | INCREASES ACTIVITY OF | Somatostatin Receptor Type 5 |
| Somatostatin Receptor Type 1 | PARTICIPATES IN | Negative Regulation Of Corticotropin Secretion |
| Somatostatin Receptor Type 2 | PARTICIPATES IN | Negative Regulation Of Corticotropin Secretion |
| Somatostatin Receptor Type 3 | PARTICIPATES IN | Negative Regulation Of Corticotropin Secretion |
| Somatostatin Receptor Type 5 | PARTICIPATES IN | Negative Regulation Of Corticotropin Secretion |
| Negative Regulation Of Corticotropin Secretion | PARTICIPATES IN | Negative Regulation Of Cortisol Secretion |
| Negative Regulation Of Cortisol Secretion | DECREASES ABUNDANCE OF | Cortisol |
| Cortisol | POSITIVELY CORRELATED WITH | Hypercortisolism |
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