Path ID: DB06626_MESH_D002292_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000077784 | Axitinib | Drug |
| UniProt:P17948 | Vascular endothelial growth factor receptor 1 | Protein |
| UniProt:P35968 | Vascular endothelial growth factor receptor 2 | Protein |
| UniProt:P35916 | Vascular endothelial growth factor receptor 3 | Protein |
| GO:0001525 | angiogenesis | BiologicalProcess |
| CL:0001063 | neoplastic cell | Cell |
| MESH:D002292 | Carcinoma, Renal Cell | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Axitinib | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor Receptor 1 |
| Axitinib | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor Receptor 2 |
| Axitinib | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor Receptor 3 |
| Vascular Endothelial Growth Factor Receptor 1 | POSITIVELY REGULATES | Angiogenesis |
| Vascular Endothelial Growth Factor Receptor 2 | POSITIVELY REGULATES | Angiogenesis |
| Vascular Endothelial Growth Factor Receptor 3 | POSITIVELY REGULATES | Angiogenesis |
| Angiogenesis | OCCURS IN | Neoplastic Cell |
| Neoplastic Cell | CAUSES | Carcinoma, Renal Cell |
Reference: