Path ID: DB06612_MESH_D011657_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C434107 | mepolizumab | Drug |
| UniProt:P05113 | Interleukin-5 | Protein |
| GO:0043307 | Eosinophil activation | BiologicalProcess |
| GO:0072677 | Eosinophil migration | BiologicalProcess |
| GO:0030222 | Eosinophil differentiation | BiologicalProcess |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0100699 | Scarring | PhenotypicFeature |
| MESH:D011657 | Eosinophilic asthma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mepolizumab | DECREASES ACTIVITY OF | Interleukin-5 |
| Interleukin-5 | POSITIVELY REGULATES | Eosinophil Activation |
| Interleukin-5 | POSITIVELY REGULATES | Eosinophil Migration |
| Interleukin-5 | POSITIVELY REGULATES | Eosinophil Differentiation |
| Eosinophil Activation | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Eosinophil Migration | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Eosinophil Differentiation | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Scarring |
| Scarring | OCCURS IN | Eosinophilic Asthma |
Reference: