Path ID: DB06595_MESH_D015470_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C059539 | midostaurin | Drug |
| UniProt:P36888 | Receptor-type tyrosine-protein kinase FLT3 | Protein |
| UniProt:P09619 | Platelet-derived growth factor receptor beta | Protein |
| UniProt:P16234 | Platelet-derived growth factor receptor alpha | Protein |
| UniProt:P35968 | Vascular endothelial growth factor receptor 2 | Protein |
| UniProt:P10721 | Mast/stem cell growth factor receptor Kit | Protein |
| UniProt:P17252 | Protein kinase C alpha type | Protein |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| GO:0001525 | angiogenesis | BiologicalProcess |
| reactome:R-HSA-9607240 | FLT3 Signaling | Pathway |
| GO:0035726 | common myeloid progenitor cell proliferation | BiologicalProcess |
| MESH:D015470 | Acute myeloid leukemia, disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Midostaurin | NEGATIVELY REGULATES | Receptor-Type Tyrosine-Protein Kinase Flt3 |
| Midostaurin | NEGATIVELY REGULATES | Mast/Stem Cell Growth Factor Receptor Kit |
| Midostaurin | NEGATIVELY REGULATES | Protein Kinase C Alpha Type |
| Midostaurin | NEGATIVELY REGULATES | Platelet-Derived Growth Factor Receptor Beta |
| Midostaurin | NEGATIVELY REGULATES | Platelet-Derived Growth Factor Receptor Alpha |
| Midostaurin | NEGATIVELY REGULATES | Vascular Endothelial Growth Factor Receptor 2 |
| Vascular Endothelial Growth Factor Receptor 2 | POSITIVELY REGULATES | Angiogenesis |
| Mast/Stem Cell Growth Factor Receptor Kit | POSITIVELY REGULATES | Cell Population Proliferation |
| Platelet-Derived Growth Factor Receptor Beta | POSITIVELY REGULATES | Cell Population Proliferation |
| Platelet-Derived Growth Factor Receptor Alpha | POSITIVELY REGULATES | Cell Population Proliferation |
| Protein Kinase C Alpha Type | POSITIVELY REGULATES | Angiogenesis |
| Receptor-Type Tyrosine-Protein Kinase Flt3 | POSITIVELY REGULATES | Common Myeloid Progenitor Cell Proliferation |
| Common Myeloid Progenitor Cell Proliferation | POSITIVELY CORRELATED WITH | Acute Myeloid Leukemia, Disease |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Acute Myeloid Leukemia, Disease |
| Angiogenesis | POSITIVELY CORRELATED WITH | Acute Myeloid Leukemia, Disease |
| Midostaurin | NEGATIVELY CORRELATED WITH | Flt3 Signaling |
| Flt3 Signaling | POSITIVELY CORRELATED WITH | Acute Myeloid Leukemia, Disease |
Reference: