Path ID: DB06594_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C084711 | agomelatine | Drug |
| UniProt:P28335 | 5-hydroxytryptamine receptor 2C | Protein |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| GO:0061527 | Dopamine secretion, neurotransmission | BiologicalProcess |
| UniProt:P48039 | Melatonin receptor type 1A | Protein |
| UniProt:P49286 | Melatonin receptor type 1B | Protein |
| GO:0045187 | Regulation of circadian sleep/wake cycle, sleep | BiologicalProcess |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Agomelatine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2C |
| Agomelatine | INCREASES ACTIVITY OF | Melatonin Receptor Type 1A |
| Agomelatine | INCREASES ACTIVITY OF | Melatonin Receptor Type 1B |
| 5-Hydroxytryptamine Receptor 2C | NEGATIVELY REGULATES | Norepinephrine Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | TREATS | Major Depressive Disorder |
| 5-Hydroxytryptamine Receptor 2C | NEGATIVELY REGULATES | Dopamine Secretion, Neurotransmission |
| Dopamine Secretion, Neurotransmission | TREATS | Major Depressive Disorder |
| Melatonin Receptor Type 1A | POSITIVELY REGULATES | Regulation Of Circadian Sleep/Wake Cycle, Sleep |
| Melatonin Receptor Type 1B | POSITIVELY REGULATES | Regulation Of Circadian Sleep/Wake Cycle, Sleep |
| Regulation Of Circadian Sleep/Wake Cycle, Sleep | NEGATIVELY CORRELATED WITH | Major Depressive Disorder |
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