Path ID: DB06285_MESH_D015663_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019379 | teriparatide | Drug |
| UniProt:Q03431 | Parathyroid hormone/parathyroid hormone-related peptide receptor | Protein |
| GO:0004991 | parathyroid hormone receptor activity | MolecularActivity |
| GO:0001503 | ossification | BiologicalProcess |
| GO:0002076 | osteoblast development | BiologicalProcess |
| GO:0002062 | chondrocyte differentiation | BiologicalProcess |
| HP:0004349 | Reduced bone mineral density | Disease |
| MESH:D015663 | Postmenopausal osteoporosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Teriparatide | INCREASES ACTIVITY OF | Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor |
| Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor | POSITIVELY REGULATES | Parathyroid Hormone Receptor Activity |
| Parathyroid Hormone Receptor Activity | POSITIVELY CORRELATED WITH | Ossification |
| Parathyroid Hormone Receptor Activity | POSITIVELY CORRELATED WITH | Osteoblast Development |
| Parathyroid Hormone Receptor Activity | POSITIVELY CORRELATED WITH | Chondrocyte Differentiation |
| Parathyroid Hormone Receptor Activity | POSITIVELY CORRELATED WITH | Osteoblast Development |
| Ossification | NEGATIVELY CORRELATED WITH | Reduced Bone Mineral Density |
| Osteoblast Development | NEGATIVELY CORRELATED WITH | Reduced Bone Mineral Density |
| Chondrocyte Differentiation | NEGATIVELY CORRELATED WITH | Reduced Bone Mineral Density |
| Osteoblast Development | NEGATIVELY CORRELATED WITH | Reduced Bone Mineral Density |
| Reduced Bone Mineral Density | POSITIVELY CORRELATED WITH | Postmenopausal Osteoporosis |
Comment: A right balance needs to be struck for normal bone formation, which involved bone resorption, the breaking down of bone tissue. This drug is actually a portion of the physiologically procuded hormone, PTH, which does increase bone resorption. So the right amount of drug (and frequency) is needed to be achieved to have a net effect of stimulating new bone formation therefore preventing osteoporosis.
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