Path ID: DB06283_MESH_D059350_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C078452 | Ziconotide | Drug |
| UniProt:Q00975 | Voltage-dependent N-type calcium channel subunit alpha-1B | Protein |
| GO:0007268 | Chemical synaptic transmission | BiologicalProcess |
| GO:1990793 | Substance P secretion, neurotransmission | BiologicalProcess |
| GO:0061535 | Glutamate secretion, neurotransmission | BiologicalProcess |
| InterPro:IPR015476 | Calcitonin gene-related peptide | GeneFamily |
| GO:0019233 | Sensory perception of pain | BiologicalProcess |
| MESH:D059350 | Chronic pain | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ziconotide | DECREASES ACTIVITY OF | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1B |
| Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1B | POSITIVELY REGULATES | Chemical Synaptic Transmission |
| Chemical Synaptic Transmission | POSITIVELY CORRELATED WITH | Substance P Secretion, Neurotransmission |
| Chemical Synaptic Transmission | POSITIVELY CORRELATED WITH | Glutamate Secretion, Neurotransmission |
| Chemical Synaptic Transmission | POSITIVELY REGULATES | Calcitonin Gene-Related Peptide |
| Substance P Secretion, Neurotransmission | POSITIVELY REGULATES | Sensory Perception Of Pain |
| Glutamate Secretion, Neurotransmission | POSITIVELY REGULATES | Sensory Perception Of Pain |
| Calcitonin Gene-Related Peptide | POSITIVELY REGULATES | Sensory Perception Of Pain |
| Sensory Perception Of Pain | OCCURS IN | Chronic Pain |
Reference: