Path ID: DB06262_MESH_D007024_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D015103 | Droxidopa | Drug |
| MESH:D009638 | Norepinephrine | ChemicalSubstance |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| MESH:D007024 | Orthostatic hypotension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Droxidopa | HAS METABOLITE | Norepinephrine |
| Norepinephrine | INCREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Norepinephrine | INCREASES ACTIVITY OF | Alpha-1B Adrenergic Receptor |
| Norepinephrine | INCREASES ACTIVITY OF | Alpha-1D Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1B Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1D Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Orthostatic Hypotension |
Reference: